Nature Communications (Feb 2020)

Deriving disease modules from the compressed transcriptional space embedded in a deep autoencoder

  • Sanjiv K. Dwivedi,
  • Andreas Tjärnberg,
  • Jesper Tegnér,
  • Mika Gustafsson

DOI
https://doi.org/10.1038/s41467-020-14666-6
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 10

Abstract

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The study of disease modules facilitates insight into complex diseases, but their identification relies on knowledge of molecular networks. Here, the authors show that disease modules and genes can also be discovered in deep autoencoder representations of large human gene expression datasets.