Fast Phase-Contrast Cine MRI for Assessing Intracranial Hemodynamics and Cerebrospinal Fluid Dynamics
Naoki Ohno,
Tosiaki Miyati,
Tomohiro Noda,
Noam Alperin,
Takashi Hamaguchi,
Masako Ohno,
Tatsuhiko Matsushita,
Mitsuhito Mase,
Toshifumi Gabata,
Satoshi Kobayashi
Affiliations
Naoki Ohno
Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 9200942, Ishikawa, Japan
Tosiaki Miyati
Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 9200942, Ishikawa, Japan
Tomohiro Noda
Department of Radiology, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 6500017, Hyogo, Japan
Noam Alperin
Department of Radiology, University of Miami, 1150 NW 14th Street, Suite 713, Miami, FL 33136, USA
Takashi Hamaguchi
Department of Radiological Technology, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa 9208641, Ishikawa, Japan
Masako Ohno
Department of Radiological Technology, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa 9208641, Ishikawa, Japan
Tatsuhiko Matsushita
Division of Clinical Radiology Service, Kyoto University Hospital, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 6068507, Japan
Mitsuhito Mase
Department of Neurosurgery, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 4678601, Aichi, Japan
Toshifumi Gabata
Department of Radiology, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa 9208641, Ishikawa, Japan
Satoshi Kobayashi
Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 9200942, Ishikawa, Japan
We propose fast phase-contrast cine magnetic resonance imaging (PC-cine MRI) to allow breath-hold acquisition, and we compared intracranial hemo- and hydrodynamic parameters obtained during breath holding between full inspiration and end expiration. On a 3.0 T MRI, using electrocardiogram (ECG)-synchronized fast PC-cine MRI with parallel imaging, rectangular field of view, and segmented k-space, we obtained velocity-mapped phase images at the mid-C2 level with different velocity encoding for transcranial blood flow and cerebrospinal-fluid (CSF) flow. Next, we calculated the peak-to-peak amplitudes of cerebral blood flow (ΔCBF), cerebral venous outflow, intracranial volume change, CSF pressure gradient (ΔPG), and intracranial compliance index. These parameters were compared between the proposed and conventional methods. Moreover, we compared these parameters between different utilized breath-hold maneuvers (inspiration, expiration, and free breathing). All parameters derived from the fast PC method agreed with those from the conventional method. The ΔPG was significantly higher during full inspiration breath holding than at the end of expiration and during free breathing. The proposed fast PC-cine MRI reduced scan time (within 30 s) with good agreement with conventional methods. The use of this method also makes it possible to assess the effects of respiration on intracranial hemo- and hydrodynamics.
