Nature Communications (Mar 2023)
Post-acute sequelae of COVID-19 is characterized by diminished peripheral CD8+β7 integrin+ T cells and anti-SARS-CoV-2 IgA response
- André Santa Cruz,
- Ana Mendes-Frias,
- Marne Azarias-da-Silva,
- Sónia André,
- Ana Isabel Oliveira,
- Olga Pires,
- Marta Mendes,
- Bárbara Oliveira,
- Marta Braga,
- Joana Rita Lopes,
- Rui Domingues,
- Ricardo Costa,
- Luís Neves Silva,
- Ana Rita Matos,
- Cristina Ângela,
- Patrício Costa,
- Alexandre Carvalho,
- Carlos Capela,
- Jorge Pedrosa,
- António Gil Castro,
- Jérôme Estaquier,
- Ricardo Silvestre
Affiliations
- André Santa Cruz
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Ana Mendes-Frias
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Marne Azarias-da-Silva
- INSERM-U1124, Université Paris Cité
- Sónia André
- INSERM-U1124, Université Paris Cité
- Ana Isabel Oliveira
- Department of Internal Medicine, Hospital of Braga
- Olga Pires
- Department of Internal Medicine, Hospital of Braga
- Marta Mendes
- Department of Internal Medicine, Hospital of Braga
- Bárbara Oliveira
- Department of Internal Medicine, Hospital of Braga
- Marta Braga
- Department of Internal Medicine, Hospital of Braga
- Joana Rita Lopes
- Department of Internal Medicine, Hospital of Braga
- Rui Domingues
- Department of Internal Medicine, Hospital of Braga
- Ricardo Costa
- Department of Internal Medicine, Hospital of Braga
- Luís Neves Silva
- Department of Internal Medicine, Hospital of Braga
- Ana Rita Matos
- Department of Internal Medicine, Hospital of Braga
- Cristina Ângela
- Department of Internal Medicine, Hospital of Braga
- Patrício Costa
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Alexandre Carvalho
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Carlos Capela
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Jorge Pedrosa
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- António Gil Castro
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Jérôme Estaquier
- INSERM-U1124, Université Paris Cité
- Ricardo Silvestre
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- DOI
- https://doi.org/10.1038/s41467-023-37368-1
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 14
Abstract
Post-acute sequelae SARS-CoV-2 (PASC), also known as long COVID is a chronic and often debilitating condition that develops following acute disease. Here authors show that individuals who suffer from PASC symptoms at six month following infection are characterized by persisting immunological disfunction, affecting cellular and humoral components of mucosal immunity.
