Biomolecules (Sep 2017)

Self-Assembly of Human Serum Albumin: A Simplex Phenomenon

  • Garima Thakur,
  • Kovur Prashanthi,
  • Keren Jiang,
  • Thomas Thundat

DOI
https://doi.org/10.3390/biom7030069
Journal volume & issue
Vol. 7, no. 3
p. 69

Abstract

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Spontaneous self-assemblies of biomolecules can generate geometrical patterns. Our findings provide an insight into the mechanism of self-assembled ring pattern generation by human serum albumin (HSA). The self-assembly is a process guided by kinetic and thermodynamic parameters. The generated protein ring patterns display a behavior which is geometrically related to a n-simplex model and is explained through thermodynamics and chemical kinetics.

Keywords