Side Effects of Basic Therapy in Children with Allergic Asthma

Abstract

Objective — to detect side effects of basic therapy in children with allergic bronchial asthma (BA). Materials and Methods. The study involved 224 children with allergic BA aged 6 to 17 years, with evaluation of homocysteine and vascular endothelial growth factor levels, ultrasonography of the carotid and brachial artery on Philips HD11 XE device in B-mode with color Doppler flow mapping. Results. When comparing content of homocysteine and vascular endothelial growth factor in children with BA depending on basic anti-inflammatory therapy (BAIT), we have found that their content is significantly lower in children who did not receive BAIT (p < 0.05). Treatment with average and high doses of inhaled glucocorticoids is a risk factor for increase in homocysteine level (odds ration (OR) 1.504; 95% CI (confident interval) 1.141–7.519, and OR 2.456; 95% CI 1.427–29.343, respectively). The content of vascular endothelial growth factor significantly increased with the use of low (OR 1.385; 95% CI 1.117–4.602) and average (OR 2.462; 95% CI 1.200–30.275) doses of inhaled glucocorticoids. Intima-media thickening more than 0.9 mm (OR 1.157; 95% CI 1.080–4.777) hadn’t dose-dependent effect.

Keywords

• children
• bronchial asthma
• endothelial dysfunction
• adverse effects of treatment.