Nature Communications (Mar 2020)
2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations
- Carole Trzaska,
- Séverine Amand,
- Christine Bailly,
- Catherine Leroy,
- Virginie Marchand,
- Evelyne Duvernois-Berthet,
- Jean-Michel Saliou,
- Hana Benhabiles,
- Elisabeth Werkmeister,
- Thierry Chassat,
- Romain Guilbert,
- David Hannebique,
- Anthony Mouray,
- Marie-Christine Copin,
- Pierre-Arthur Moreau,
- Eric Adriaenssens,
- Andreas Kulozik,
- Eric Westhof,
- David Tulasne,
- Yuri Motorin,
- Sylvie Rebuffat,
- Fabrice Lejeune
Affiliations
- Carole Trzaska
- Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, UMR9020–UMR-S 1277, CANTHER – Cancer Heterogeneity, Plasticity and Resistance to Therapies
- Séverine Amand
- Muséum National d’Histoire Naturelle, Centre National de la Recherche Scientifique, Laboratory Molecules of Communication and Adaptation of Microorganisms (MCAM), UMR 7245 CNRS-MNHN
- Christine Bailly
- Muséum National d’Histoire Naturelle, Centre National de la Recherche Scientifique, Laboratory Molecules of Communication and Adaptation of Microorganisms (MCAM), UMR 7245 CNRS-MNHN
- Catherine Leroy
- Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, UMR9020–UMR-S 1277, CANTHER – Cancer Heterogeneity, Plasticity and Resistance to Therapies
- Virginie Marchand
- Next-Generation Sequencing Core Facility, UMS2008 IBSLor CNRS-Université de Lorraine-INSERM
- Evelyne Duvernois-Berthet
- Muséum National d’Histoire Naturelle, Centre National de la Recherche Scientifique, Laboratoire Physiologie Moléculaire et Adaptation (PhyMA), UMR7221 CNRS-MNHN
- Jean-Michel Saliou
- CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019, UMR 8204, CIIL‑Centre d’Infection et d’Immunité de Lille, University of Lille
- Hana Benhabiles
- Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, UMR9020–UMR-S 1277, CANTHER – Cancer Heterogeneity, Plasticity and Resistance to Therapies
- Elisabeth Werkmeister
- Cellular Microbiology and Physics of Infection Group, Center for Infection and Immunity of Lille, CNRS UMR8204, INSERM U1019, Institut Pasteur de Lille, Lille Regional Univ. Hosp. Centr., Lille Univ.
- Thierry Chassat
- Institut Pasteur de Lille – PLEHTA (Plateforme d’expérimentation et de Haute Technologie Animale)
- Romain Guilbert
- Institut Pasteur de Lille – PLEHTA (Plateforme d’expérimentation et de Haute Technologie Animale)
- David Hannebique
- Institut Pasteur de Lille – PLEHTA (Plateforme d’expérimentation et de Haute Technologie Animale)
- Anthony Mouray
- Institut Pasteur de Lille – PLEHTA (Plateforme d’expérimentation et de Haute Technologie Animale)
- Marie-Christine Copin
- Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, UMR9020–UMR-S 1277, CANTHER – Cancer Heterogeneity, Plasticity and Resistance to Therapies
- Pierre-Arthur Moreau
- Univ. Lille, Fac. Pharmacie Lille, ULR 4515, LGCgE, Laboratoire de Génie Civil et géo-Environnement
- Eric Adriaenssens
- Univ. Lille, CNRS, INSERM, CHU.Lille, Centre Oscar Lambert, UMR9020–UMR1277, CANTHER – Cancer Heterogeneity, Plasticity and Résistance to Therapies
- Andreas Kulozik
- Department of Pediatric Oncology, Hematology and Immunology, Children’s Hospital and Hopp Children’s Tumor Center Heidelberg, EMBL/Medical Faculty Molecular Medicine Partnership Unit
- Eric Westhof
- Architecture and Reactivity of RNA, Institute of Molecular and Cellular Biology of the CNRS UPR9002/University of Strasbourg
- David Tulasne
- Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, UMR9020–UMR-S 1277, CANTHER – Cancer Heterogeneity, Plasticity and Resistance to Therapies
- Yuri Motorin
- Ingénierie Moléculaire et Physiopathologie Articulaire, UMR7365, CNRS - Université de Lorraine
- Sylvie Rebuffat
- Muséum National d’Histoire Naturelle, Centre National de la Recherche Scientifique, Laboratory Molecules of Communication and Adaptation of Microorganisms (MCAM), UMR 7245 CNRS-MNHN
- Fabrice Lejeune
- Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, UMR9020–UMR-S 1277, CANTHER – Cancer Heterogeneity, Plasticity and Resistance to Therapies
- DOI
- https://doi.org/10.1038/s41467-020-15140-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Nonsense mutations can be corrected by several molecules that activate readthrough of premature termination codon. Here, the authors report that 2,6-diaminopurine efficiently corrects UGA nonsense mutations with no significant toxicity.
