Whipple's disease in a patient with infantile cerebral palsy and hepatitis B virus cirrhosis

Abstract

The paper describes a patient who has developed Whipple's disease in the presence of infantile cerebral palsy and hepatitis B virus cirrhosis. After 5-year treatment with co-trimoxazole (480 mg b.i.d.), the clinical manifestations subsided and PAS-positive macrophages were no longer detectable in the small intestinal mucosal biopsy specimens. Subsequent worsening of the patient's condition was associated with the progression of liver cirrhosis.

Keywords

• whipple's disease
• infantile cerebral palsy
• liver cirrhosis