Mapping the spreading routes of lymphatic metastases in human colorectal cancer

Chong Zhang; Lin Zhang; Tianlei Xu; Ruidong Xue; Liang Yu; Yuelu Zhu; Yunlong Wu; Qingqing Zhang; Dongdong Li; Shuohao Shen; Dongfeng Tan; Fan Bai; Haizeng Zhang

doi:10.1038/s41467-020-15886-6

Nature Communications (Apr 2020)

Mapping the spreading routes of lymphatic metastases in human colorectal cancer

Chong Zhang,
Lin Zhang,
Tianlei Xu,
Ruidong Xue,
Liang Yu,
Yuelu Zhu,
Yunlong Wu,
Qingqing Zhang,
Dongdong Li,
Shuohao Shen,
Dongfeng Tan,
Fan Bai,
Haizeng Zhang

Affiliations

Chong Zhang: Biomedical Pioneering Innovation Center (BIOPIC) and Translational Cancer Research Center, School of Life Sciences, First Hospital, Peking University
Lin Zhang: Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Tianlei Xu: Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Ruidong Xue: Biomedical Pioneering Innovation Center (BIOPIC) and Translational Cancer Research Center, School of Life Sciences, First Hospital, Peking University
Liang Yu: Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Yuelu Zhu: Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Yunlong Wu: Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Qingqing Zhang: Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Dongdong Li: Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Shuohao Shen: Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Dongfeng Tan: Department of Pathology and GI Medical Oncology, The University of Texas M. D. Anderson Cancer Center
Fan Bai: Biomedical Pioneering Innovation Center (BIOPIC) and Translational Cancer Research Center, School of Life Sciences, First Hospital, Peking University
Haizeng Zhang: Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

DOI: https://doi.org/10.1038/s41467-020-15886-6
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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Lymphatic metastases are closely associated with tumor relapse and reduced survival in colorectal cancer (CRC). Here, the authors analysed the primary tumours, lymph node metastasis and liver metastasis of ten CRC patients and reveal co-existence of diverse modes of metastasis in the same patient.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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