Progress in experimental models of cholangiocarcinoma

Abstract

Cholangiocarcinoma is the second most common malignant tumor of the liver，which is characterized by atypical early symptoms，high malignancy and high mortality. Currently，the overall incidence of cholangiocarcinoma has been increased year by year worldwide and a majority of cholangiocarcinoma patients obtain poor prognosis. Effective diagnosis and treatment strategies are urgently required to change this situation. The establishment of disease models is a hot topic in cancer research. The establishment of experimental models of cholangiocarcinoma contributes to in-depth understanding and study of the incidence，development and drug therapeutic effect of cholangiocarcinoma，which is of significance for early diagnosis and treatment of cholangiocarcinoma.

Keywords

• cholangiocarcinoma|in<i> vitro</i> model|3d printing|in<i> vivo</i> model|crispr/cas9|genetic engineering