Nature Communications (Jun 2018)

A mixed antagonistic/synergistic miRNA repression model enables accurate predictions of multi-input miRNA sensor activity

  • Jeremy J. Gam,
  • Jonathan Babb,
  • Ron Weiss

DOI
https://doi.org/10.1038/s41467-018-04575-0
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression but many quantitative aspects of miRNA biology remain to be elucidated. Based on a library of miRNA sensors, the authors quantify miRNA regulation at single cell level and develop a model to predict miRNA target interactions.