Nature Communications (Jun 2018)
A mixed antagonistic/synergistic miRNA repression model enables accurate predictions of multi-input miRNA sensor activity
Abstract
MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression but many quantitative aspects of miRNA biology remain to be elucidated. Based on a library of miRNA sensors, the authors quantify miRNA regulation at single cell level and develop a model to predict miRNA target interactions.