Impact of 10-valent Pneumococcal Conjugate Vaccine (PCV10) on nasopharyngeal carriage in children 2 years of age: Data from a four-year time series cross-sectional study from Pakistan
Muhammad Imran Nisar,
Shahira Shahid,
Sajid Muhammad,
Farah Khalid,
Amjad Hussain,
Sheraz Ahmed,
Sadia Shakoor,
Furqan Kabir,
Aneeta Hotwani,
Asad Ali,
Anita KM Zaidi,
Saad B Omer,
Fyezah Jehan,
Najeeha Iqbal
Affiliations
Muhammad Imran Nisar
Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan; Corresponding author(s).
Shahira Shahid
Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan
Sajid Muhammad
Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan
Farah Khalid
Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan
Amjad Hussain
Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan
Sheraz Ahmed
Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan
Sadia Shakoor
Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan
Furqan Kabir
Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan
Aneeta Hotwani
Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan
Asad Ali
Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan
Anita KM Zaidi
Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan; Bill & Melinda Gates Foundation, Seattle, WA, USA
Saad B Omer
Yale Institute for Global Health, New Haven, CT, USA
Fyezah Jehan
Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan
Najeeha Iqbal
Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan
The dataset described in this paper was collected for a time-series cross-sectional study exploring the impact of 10-valent Pneumococcal Conjugate Vaccine (PCV10) on nasopharyngeal (NP) carriage in children under 2 years of age from a rural population in Sindh, Pakistan. The study was carried out in two union councils of Matiari - Khyber and Shah Alam Shah Jee Wasi (Latitude 25.680298 / Longitude 68.502711). Data was collected on socio-demographics, clinical characteristics and vaccination status using android phone-based application. NP samples were collected using standard World Health Organisation (WHO) techniques, culture and serotyping was done using sequential Multiplex PCR described by Centre for Disease Control, USA. We looked at the carriage rate of vaccine type (VT) and non-vaccine type (NVT) serotypes over time in vaccinated and unvaccinated children. We additionally looked at the predictors for pneumococcal carriage. The uploaded dataset, available on Mendeley data repository (Nisar, Muhammad Imran (2021), “Impact of PCV10 on nasopharyngeal carriage in children in Pakistan”, Mendeley Data, V1, doi:10.17632/t79h6g97gr.1), has 3140 observations in CSV format. Additional files uploaded include a data dictionary and the set of questionnaires. The dataset and accompanying files can be used by other interested researchers to replicate our analysis, carry similar analysis under varying set of assumptions or perform additional exploratory or metanalysis
