Antibacterial Mechanism of Patrinia scabiosaefolia Against Methicillin Resistant Staphylococcus epidermidis

Abstract

Xin Liu,1 Lili An,2 Yonghui Zhou,1 Wei Peng,1 Cong Huang1 1College of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang City, People’s Republic of China; 2Dermatology Department, the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang City, People’s Republic of ChinaCorrespondence: Xin Liu, College of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang City, People’s Republic of China, Tel [phone], Email [email protected]: Staphylococcus epidermidis has become one of the most common causes of septicemia. Meanwhile, S. epidermidis has acquired resistance to many antibiotics. Among these, methicillin-resistant S. epidermidis (MRSE) were frequently isolated. Similar to methicillin resistant Staphylococcus aureus (MRSA), they also exhibited multi-resistance, which presented a danger to human health. Patrinia scabiosaefolia as traditional Chinese medicine had strong antibacterial activity against MRSE. However, the mechanism of P. scabiosaefolia against MRSE is not clear.Methods: Here, the morphology of cell wall and cell membrane, production of β-lactamase and PBP2, energy metabolism, antioxidant system were systematically studied.Results: The data showed that P. scabiosaefolia damaged the cell wall and membrane. In addition, β-lactamase, energy metabolism and antioxidant system were involved in mechanisms of P. scabiosaefolia against MRSE.Conclusion: These observations provided new understanding of P. scabiosaefolia against MRSE to control MRSE infections.Keywords: methicillin-resistantStaphylococcus epidermidis, Patrinia scabiosifolia, β-lactamase, energy metabolism, antioxidant system

Keywords

• methicillin-resistant staphylococcus epidermidis
• patrinia scabiosaefolia
• β-lactamase
• energy metabolism
• antioxidant system;