Nature Communications (Jul 2019)
Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases
- Jing Sun,
- Cheng Wang,
- Yi Zhang,
- Lingyan Xu,
- Weijia Fang,
- Yuping Zhu,
- Yi Zheng,
- Xiaofeng Chen,
- Xiju Xie,
- Xinhua Hu,
- Weidong Hu,
- Jingyu Zheng,
- Ping Li,
- Jian Yu,
- Zhu Mei,
- Xiaomin Cai,
- Biao Wang,
- Zhibin Hu,
- Yongqian Shu,
- Hongbing Shen,
- Yanhong Gu
Affiliations
- Jing Sun
- Department of Oncology, The First Affiliated Hospital of Nanjing Medical University
- Cheng Wang
- Department of Epidemiology and Biostatistics, School of Public Health; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University
- Yi Zhang
- Department of General Surgery, The First Affiliated Hospital of Nanjing University of Chinese Medicine
- Lingyan Xu
- Department of Oncology, The First Affiliated Hospital of Nanjing Medical University
- Weijia Fang
- Cancer Biotherapy Center, The First Affiliated Hospital, School of Medicine, Zhejiang University
- Yuping Zhu
- Department of Colorectal Surgery, The Zhejiang Cancer Hospital
- Yi Zheng
- Cancer Biotherapy Center, The First Affiliated Hospital, School of Medicine, Zhejiang University
- Xiaofeng Chen
- Department of Oncology, The First Affiliated Hospital of Nanjing Medical University
- Xiju Xie
- Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University
- Xinhua Hu
- Department of neurosurgery, The Affiliated Brain Hospital of Nanjing Medical University
- Weidong Hu
- Department of Neurology, The Second Affiliated Hospital of Soochow University
- Jingyu Zheng
- Department of Pathology, The Affiliated Drum Tower Hospital, Nanjing University Medical School
- Ping Li
- Department of Oncology, The First Affiliated Hospital of Nanjing Medical University
- Jian Yu
- Department of Pathology and Radiation Oncology, University of Pittsburgh School of Medicine
- Zhu Mei
- Department of Oncology, The First Affiliated Hospital of Nanjing Medical University
- Xiaomin Cai
- Department of Oncology, The First Affiliated Hospital of Nanjing Medical University
- Biao Wang
- Department of Oncology, The First Affiliated Hospital of Nanjing Medical University
- Zhibin Hu
- Department of Epidemiology and Biostatistics, School of Public Health; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University
- Yongqian Shu
- Department of Oncology, The First Affiliated Hospital of Nanjing Medical University
- Hongbing Shen
- Department of Epidemiology and Biostatistics, School of Public Health; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University
- Yanhong Gu
- Department of Oncology, The First Affiliated Hospital of Nanjing Medical University
- DOI
- https://doi.org/10.1038/s41467-019-10987-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 9
Abstract
The development of brain metastases is a lethal yet poorly understood event in the evolution of many cancers. Here, the authors perform whole-genome and whole-exome sequencing on matched normal, primary and metastatic tissue samples to explore the genomic features of brain metastases in colorectal cancer.
