A Prospective, Multicenter, Observational Registry (ReCoRD) on Demography, Molecular Profile, Clinical Features, and Treatment Outcomes in Individuals undergoing Treatment for Metastatic Colorectal Cancer

Abstract

Objective: Out of all newly diagnosed colorectal cancer cases globally, 20% of the patients present with metastasis, and 25% develop metastasis later. The 5-year survival rate after diagnosis for mCRC patients is <20%. Although many studies using population-based cancer registries from India are available on various cancers, data on mCRC in India is scarce. Therefore, the purpose of the ReCoRD registry is to obtain real world data on demographics, treatment pattern and outcomes in Indian patients with mCRC. Methods: This is a prospective, multicenter, observational study on 1000 participants with mCRC, who are enrolled in the registry in up to 15 centers for 2 years. The recruitment will be stopped 2 years following the first patient enrollment. A minimum follow-up of 12–18 months is being carried out post-enrollment in the registry. Data on the demography, clinical features, molecular profile, treatment options, and outcomes of treatment for these patients is being collected from the study sites by investigators. The Kaplan-Meier Plot will be utilized to examine the survival data, and the median time computed by the Kaplan-Meier technique will be presented with a confidence interval of 95%. Conclusion: Although mCRC remains incurable in most cases, survival rates have improved with the advent of newer cytotoxic chemotherapeutic drugs and targeted agents. The ReCoRD registry will collect details of the demography, tumor characteristics, molecular aspects, treatment, and treatment outcomes in individuals with mCRC, which can guide the clinicians in decision making and treatment based on Indian patient data.

Keywords

• colorectal neoplasms, india, neoplasm metastasis, ras genes.