Nature Communications (Apr 2020)
α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease
- Cecilia S. Lindestam Arlehamn,
- Rekha Dhanwani,
- John Pham,
- Rebecca Kuan,
- April Frazier,
- Juliana Rezende Dutra,
- Elizabeth Phillips,
- Simon Mallal,
- Mario Roederer,
- Karen S. Marder,
- Amy W. Amara,
- David G. Standaert,
- Jennifer G. Goldman,
- Irene Litvan,
- Bjoern Peters,
- David Sulzer,
- Alessandro Sette
Affiliations
- Cecilia S. Lindestam Arlehamn
- Division of Vaccine Discovery, La Jolla Institute for Immunology
- Rekha Dhanwani
- Division of Vaccine Discovery, La Jolla Institute for Immunology
- John Pham
- Division of Vaccine Discovery, La Jolla Institute for Immunology
- Rebecca Kuan
- Division of Vaccine Discovery, La Jolla Institute for Immunology
- April Frazier
- Division of Vaccine Discovery, La Jolla Institute for Immunology
- Juliana Rezende Dutra
- Department of Neurology, Columbia University Medical Center
- Elizabeth Phillips
- Vanderbilt University School of Medicine
- Simon Mallal
- Vanderbilt University School of Medicine
- Mario Roederer
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Karen S. Marder
- Department of Neurology, Columbia University Medical Center
- Amy W. Amara
- Department of Neurology, University of Alabama at Birmingham
- David G. Standaert
- Department of Neurology, University of Alabama at Birmingham
- Jennifer G. Goldman
- Shirley Ryan AbilityLab, Northwestern University Feinberg School of Medicine
- Irene Litvan
- Department of Neurology, University of California San Diego
- Bjoern Peters
- Division of Vaccine Discovery, La Jolla Institute for Immunology
- David Sulzer
- Department of Neurology, Columbia University
- Alessandro Sette
- Division of Vaccine Discovery, La Jolla Institute for Immunology
- DOI
- https://doi.org/10.1038/s41467-020-15626-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
α-Synuclein-specific T cell reactivity is preferentially associated with Parkinson’s disease (PD) patients, but the temporal relation with diagnosis was previously unknown. This study reveals that α-syn-reactive T cells are highest before and shortly after diagnosis of motor PD, and then decrease.
