Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice

Abstract

During the maternal-to-zygotic transition there is degradation of maternal proteins via the ubiquitin-proteasome system (UPS). Here, the authors show that in the embryo the maternally inherited epigenetic factor DPPA3/Stella/PGC7 is cleavage by the UPS and controls intracellular trafficking.