Tissue mechanics drives regeneration of a mucociliated epidermis on the surface of Xenopus embryonic aggregates

Hye Young Kim; Timothy R. Jackson; Carsten Stuckenholz; Lance A. Davidson

doi:10.1038/s41467-020-14385-y

Nature Communications (Jan 2020)

Tissue mechanics drives regeneration of a mucociliated epidermis on the surface of Xenopus embryonic aggregates

Hye Young Kim,
Timothy R. Jackson,
Carsten Stuckenholz,
Lance A. Davidson

Affiliations

Hye Young Kim: Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh
Timothy R. Jackson: Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh
Carsten Stuckenholz: Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh
Lance A. Davidson: Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh

DOI: https://doi.org/10.1038/s41467-020-14385-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

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The role of tissue mechanics in the regeneration of mucociliated epithelium in Xenopus is unclear. Here, the authors show that Xenopus ectoderm aggregates undergo epithelial-like phenotypic transition prior to differentiation of mucus-secreting goblet cells to enable regeneration.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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