PLACE OF LOW-MOLECULAR-WEIGHT HEPARINS IN INTENSIVE THERAPY OF HEPATIC INSUFFICIENCY

Abstract

The practical significance of heparin low-molecular fractions as inhibitors of inflammation and antithrombin III consumption reduction were studied. That is most critical in acute hepatic failure. The study was performed using the low-molecular-weight heparin (Nadroparin calcium) in low (prophylactic) doses of 2000 anti-factor Xa units daily per 1 meter squared in the form of continuous intravenous infusion. The cohort study proved the nadroparin positive effect on carbohydrate and protein metabolism in children with acute poisoning by hepatotoxic poisons, The significant decrease in the quantitative assessment of disseminated intravascular coagulation relative to the comparison group has been revealed, and the decrease in 28-day mortality from 42 to 13 % has been found in children receiving nadroparin. Conclusions are drawn on the feasibility of introducing low molecular weight heparins into the intensive care regimen of liver failure.

Keywords

• low-molecular-weight heparins
• hepatic failure
• intensive therapy