Journal of Clinical Medicine (Jan 2022)
Right Heart Pulmonary Circulation Unit Response to Exercise in Patients with Controlled Systemic Arterial Hypertension: Insights from the RIGHT Heart International NETwork (RIGHT-NET)
- Olga Vriz,
- Paolo Palatini,
- Lawrence Rudski,
- Paolo Frumento,
- Jarosław D. Kasprzak,
- Francesco Ferrara,
- Rosangela Cocchia,
- Luna Gargani,
- Karina Wierzbowska-Drabik,
- Valentina Capone,
- Brigida Ranieri,
- Andrea Salzano,
- Anna Agnese Stanziola,
- Alberto Maria Marra,
- Roberto Annunziata,
- Salvatore Chianese,
- Salvatore Rega,
- Teresa Saltalamacchia,
- Renato Maramaldi,
- Chiara Sepe,
- Giuseppe Limongelli,
- Filippo Cademartiri,
- Antonello D’Andrea,
- Michele D’Alto,
- Raffaele Izzo,
- Nicola Ferrara,
- Ciro Mauro,
- Antonio Cittadini,
- Grünig Ekkehard,
- Marco Guazzi,
- Eduardo Bossone
Affiliations
- Olga Vriz
- Cardiac Centre, King Faisal Specialist Hospital and Research Center, Riyadh 11564, Saudi Arabia
- Paolo Palatini
- Department of Medicine, University of Padova, 35122 Padova, Italy
- Lawrence Rudski
- Azrieli Heart Center and Center for Pulmonary Vascular Diseases, Jewish General Hospital, McGill University, Montreal, QC H3A 0G4, Canada
- Paolo Frumento
- Department of Political Sciences, University of Pisa, 56126 Pisa, Italy
- Jarosław D. Kasprzak
- Department of Cardiology, Bieganski Hospital, Medical University, 91-347 Lodz, Poland
- Francesco Ferrara
- Heart Department, University Hospital of Salerno, 84131 Salerno, Italy
- Rosangela Cocchia
- Division of Cardiology, A Cardarelli Hospital, 80131 Naples, Italy
- Luna Gargani
- Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy
- Karina Wierzbowska-Drabik
- Department of Cardiology, Bieganski Hospital, Medical University, 91-347 Lodz, Poland
- Valentina Capone
- Division of Cardiology, A Cardarelli Hospital, 80131 Naples, Italy
- Brigida Ranieri
- IRCCS Synlab SDN, 80143 Naples, Italy
- Andrea Salzano
- IRCCS Synlab SDN, 80143 Naples, Italy
- Anna Agnese Stanziola
- Department of Respiratory Diseases, Monaldi Hospital, University “Federico II”, 80131 Naples, Italy
- Alberto Maria Marra
- Department of Translational Medical Sciences, “Federico II” University of Naples, 80138 Naples, Italy
- Roberto Annunziata
- Division of Cardiology, A Cardarelli Hospital, 80131 Naples, Italy
- Salvatore Chianese
- Division of Cardiology, A Cardarelli Hospital, 80131 Naples, Italy
- Salvatore Rega
- Department of Translational Medical Sciences, “Federico II” University of Naples, 80138 Naples, Italy
- Teresa Saltalamacchia
- Department of Translational Medical Sciences, “Federico II” University of Naples, 80138 Naples, Italy
- Renato Maramaldi
- Department of Translational Medical Sciences, “Federico II” University of Naples, 80138 Naples, Italy
- Chiara Sepe
- Division of Cardiology, A Cardarelli Hospital, 80131 Naples, Italy
- Giuseppe Limongelli
- Division of Cardiology, Monaldi Hospital, Second University of Naples, 81100 Naples, Italy
- Filippo Cademartiri
- IRCCS Synlab SDN, 80143 Naples, Italy
- Antonello D’Andrea
- Department of Cardiology and Intensive Coronary Unit, “Umberto I” Hospital, 84014 Nocera Inferiore, Italy
- Michele D’Alto
- Division of Cardiology, Monaldi Hospital, Second University of Naples, 81100 Naples, Italy
- Raffaele Izzo
- Department of Advanced Biomedical Sciences, “Federico II” University of Naples, 80131 Naples, Italy
- Nicola Ferrara
- Department of Translational Medical Sciences, “Federico II” University of Naples, 80138 Naples, Italy
- Ciro Mauro
- Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy
- Antonio Cittadini
- Department of Translational Medical Sciences, “Federico II” University of Naples, 80138 Naples, Italy
- Grünig Ekkehard
- Centre for Pulmonary Hypertension, Thoraxklinik at Heidelberg University Hospital, Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), 69120 Heidelberg, Germany
- Marco Guazzi
- Heart Failure Unit, Cardiopulmonary Laboratory, University Cardiology Department, IRCCS Policlinico San Donato University Hospital, 20097 Milan, Italy
- Eduardo Bossone
- Division of Cardiology, A Cardarelli Hospital, 80131 Naples, Italy
- DOI
- https://doi.org/10.3390/jcm11020451
- Journal volume & issue
-
Vol. 11,
no. 2
p. 451
Abstract
Background. Systemic arterial hypertension (HTN) is the main risk factor for the development of heart failure with preserved ejection fraction (HFpEF). The aim of the study was was to assess the trends in PASP, E/E’ and TAPSE during exercise Doppler echocardiography (EDE) in hypertensive (HTN) patients vs. healthy subjects stratified by age. Methods. EDE was performed in 155 hypertensive patients and in 145 healthy subjects (mean age 62 ± 12.0 vs. 54 ± 14.9 years respectively, p p p = 0.011 for TAPSE). At peak exercise, the oldest group of hypertensive patients had a mean E/E’ of 13.0, suggesting a significant increase in LV diastolic pressure combined with increased PASP. Conclusion. Age and HTN have a synergic negative effect on E/E’ and TAPSE at peak exercise in hypertensive subjects.
Keywords
