Nature Communications (May 2018)

Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer

  • Myoung-Hee Kang,
  • Hyunji Choi,
  • Masanobu Oshima,
  • Jae-Ho Cheong,
  • Seokho Kim,
  • Jung Hoon Lee,
  • Young Soo Park,
  • Hueng-Sik Choi,
  • Mi-Na Kweon,
  • Chan-Gi Pack,
  • Ju-Seog Lee,
  • Gordon B. Mills,
  • Seung-Jae Myung,
  • Yun-Yong Park

DOI
https://doi.org/10.1038/s41467-018-04244-2
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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Very little is known regarding the molecular mechanisms involved in gastric cancer development. Here the authors show estrogen-related receptor gamma (ESRRG) is a tumor suppressor in gastric cancer and suggest the mechanism of this tumor suppression function involves the inhibition of Wnt signaling.