Salud UIS (Apr 2014)

Comparison of the ATB® Fungus 2 with the AFST-EUCAST for in vitro susceptibility testing of Candida spp

  • Jehidys Estella Montiel Ramos,
  • Andrea Corrales Bernal,
  • María Paulina Vélez Bravo,
  • Armando Baena Zapata,
  • Ana Cecilia Mesa Arango

Journal volume & issue
Vol. 46, no. 1
pp. 7 – 14

Abstract

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The increase of diseases caused by Candida spp., and the treatment failures, has underscored the need for testing the susceptibilities to antifungal agents. The commercial panel ATB® Fungus 2 was compared with the reference testing method of the European Subcommittee on Antifungal Susceptibility Testing of the Committee on Antimicrobial Susceptibility Testing (AFST-EUCAST) for the evaluation of the susceptibility of isolates of Candida spp. to three agents. The percentage of agreement was calculated based on the minimum inhibitory concentrations. There was a high correlation for AMB (100% қ = 1.0 Bhapkar coefficient p = 1.0); while it was lower with azoles (85%, қ = 0.41, p = Bhapkar coefficient 0.02 and 83.0%, қ = 0.15, Bhapkar coefficient p = 0.0006, respectively). The ATB® Fungus 2 and AFST-EUCAST are fully comparable methods for testing the susceptibility to AMB and to lesser extend comparable for ITR and FCA

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