Haematologica (Nov 2007)

The NQO1 C609T polymorphism is associated with risk of secondary malignant neoplasms after treatment for childhood acute lymphoblastic leukemia: a matched-pair analysis from the ALL-BFM study group

  • Martin Stanulla,
  • Christian Dynybil,
  • Dorothee B. Bartels,
  • Michael Dördelmann,
  • Lutz Löning,
  • Alexander Claviez,
  • Martin Schrappe

DOI
https://doi.org/10.3324/haematol.10260
Journal volume & issue
Vol. 92, no. 11

Abstract

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In a matched-pair study, we analyzed the association of a phenotypically relevant NQO1 polymorphism (C609T) with risk of secondary malignant neoplasms (SMN) after treatment for childhood acute lymphoblastic leukemia. Patients carrying a variant low-activity NQO1 allele had a significantly increased risk of developing a SMN. The observed effect was restricted to solid tumors.