Nature Communications (Jun 2019)

The structural basis for release-factor activation during translation termination revealed by time-resolved cryogenic electron microscopy

  • Ziao Fu,
  • Gabriele Indrisiunaite,
  • Sandip Kaledhonkar,
  • Binita Shah,
  • Ming Sun,
  • Bo Chen,
  • Robert A. Grassucci,
  • Måns Ehrenberg,
  • Joachim Frank

DOI
https://doi.org/10.1038/s41467-019-10608-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 7

Abstract

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Translation termination is under strong selection pressure for high speed and accuracy. Here the authors provide a 3D view of the dynamics of a translating bacterial ribosome as it recruits a class-1 release factor (RF1 or RF2) upon encountering a stop codon, and propose a structure-based kinetic model for the early steps in bacterial translation termination.