Nature Communications (Feb 2021)
A CSB-PAF1C axis restores processive transcription elongation after DNA damage repair
- Diana van den Heuvel,
- Cornelia G. Spruijt,
- Román González-Prieto,
- Angela Kragten,
- Michelle T. Paulsen,
- Di Zhou,
- Haoyu Wu,
- Katja Apelt,
- Yana van der Weegen,
- Kevin Yang,
- Madelon Dijk,
- Lucia Daxinger,
- Jurgen A. Marteijn,
- Alfred C. O. Vertegaal,
- Mats Ljungman,
- Michiel Vermeulen,
- Martijn S. Luijsterburg
Affiliations
- Diana van den Heuvel
- Department of Human Genetics, Leiden University Medical Center
- Cornelia G. Spruijt
- Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen
- Román González-Prieto
- Department of Cell and Chemical Biology, Leiden University Medical Center
- Angela Kragten
- Department of Human Genetics, Leiden University Medical Center
- Michelle T. Paulsen
- Department of Radiation Oncology, University of Michigan
- Di Zhou
- Department of Molecular Genetics, Oncode Institute
- Haoyu Wu
- Department of Human Genetics, Leiden University Medical Center
- Katja Apelt
- Department of Human Genetics, Leiden University Medical Center
- Yana van der Weegen
- Department of Human Genetics, Leiden University Medical Center
- Kevin Yang
- Department of Radiation Oncology, University of Michigan
- Madelon Dijk
- Department of Human Genetics, Leiden University Medical Center
- Lucia Daxinger
- Department of Human Genetics, Leiden University Medical Center
- Jurgen A. Marteijn
- Department of Molecular Genetics, Oncode Institute
- Alfred C. O. Vertegaal
- Department of Cell and Chemical Biology, Leiden University Medical Center
- Mats Ljungman
- Department of Radiation Oncology, University of Michigan
- Michiel Vermeulen
- Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen
- Martijn S. Luijsterburg
- Department of Human Genetics, Leiden University Medical Center
- DOI
- https://doi.org/10.1038/s41467-021-21520-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
The transcription-coupled repair pathway removes transcription-blocking DNA lesions, but how transcription is restored following DNA repair is not clear. Here the authors reveal that the PAF1 complex, while dispensable for the repair process, restores transcription after DNA damage.
