Secondary Lymphoma in a Patient with a History of Unilateral Retinoblastoma

Abstract

Second malignancies develop with increased incidence in patients with herediter retinoblastoma. The most common second malignancies in retinoblastoma survivors are soft tissue sarcoma and osteosarcoma. Lymphoma developing as a second malignancy has rarely been reported. Here we report a case of lymphoma diagnosed in a 13 year-old-boy, 12 years after the diagnosis of unilateral retinoblastoma having heterozygous p.R552 (c.1654C> T) mutation, treated with enucleation and radiotherapy. The risk of second tumour is higher in the hereditary retinoblastoma, especially in cases undergoing external beam radiation therapy. [Cukurova Med J 2015; 40(Suppl 1): 33-37]

Keywords

• lymphoma
• retinoblastoma
• second neoplasm
• children