Vortex-assisted supramolecular solvent dispersive liquid–liquid microextraction of ketoprofen and naproxen from environmental water before chromatographic analysis: response surface methodology optimisation

Abstract

Abstract A microextraction procedure that is rapid and simple to extract and preconcentrate ketoprofen and naproxen is proposed. An environmentally friendly supramolecular solvent was applied as an extraction solvent and proved to be efficient in the extraction of ketoprofen and naproxen from environmental water. The design of experiment approach was used to screen, optimize significant parameters, and determine optimum experimental conditions. Under optimized experimental conditions, the vortex-assisted supramolecular solvent dispersive liquid–liquid microextraction provided a good linearity (0.57–700 µg L−1), low limits of detection (0.17–0.24 µg L−1) and extraction reproducibility below 9%. The high percentage relative recoveries (93.6–101.4%) indicated that the method is not affected by matrix. The practical applicability of the method was assessed by analysing ketoprofen and naproxen in river water and effluent wastewater samples. Both analytes were found in effluent wastewater.

Keywords

• Dispersive liquid–liquid microextraction
• Supramolecular solvent
• Central composite design
• Environmental water
• Ketoprofen
• Naproxen