Communications Biology (Jan 2021)

Systemic viral spreading and defective host responses are associated with fatal Lassa fever in macaques

  • Nicolas Baillet,
  • Stéphanie Reynard,
  • Emeline Perthame,
  • Jimmy Hortion,
  • Alexandra Journeaux,
  • Mathieu Mateo,
  • Xavier Carnec,
  • Justine Schaeffer,
  • Caroline Picard,
  • Laura Barrot,
  • Stéphane Barron,
  • Audrey Vallve,
  • Aurélie Duthey,
  • Frédéric Jacquot,
  • Cathy Boehringer,
  • Grégory Jouvion,
  • Natalia Pietrosemoli,
  • Rachel Legendre,
  • Marie-Agnès Dillies,
  • Richard Allan,
  • Catherine Legras-Lachuer,
  • Caroline Carbonnelle,
  • Hervé Raoul,
  • Sylvain Baize

DOI
https://doi.org/10.1038/s42003-020-01543-7
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 19

Abstract

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Baillet et al. use the cynomolgus monkey model to model Lassa virus and associated Lassa fever (LF). They provide a full characterisation of LF pathogenesis with the aim of assisting the development of early diagnostic tools.