Nature Communications (Mar 2018)

Genetic study links components of the autonomous nervous system to heart-rate profile during exercise

  • Niek Verweij,
  • Yordi J. van de Vegte,
  • Pim van der Harst

DOI
https://doi.org/10.1038/s41467-018-03395-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9

Abstract

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Response of the heart rate (HR) to exercise is associated with cardiac fitness and risk of cardiac death. Here, in a genome-wide association study, Verweij et al. identify 23 loci for HR increase during exercise or HR recovery, and highlight pleiotropy with blood pressure by polygenic risk score analysis.