Nature Communications (Nov 2019)
Epithelial tumor suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinoma
- Katey S. S. Enfield,
- Erin A. Marshall,
- Christine Anderson,
- Kevin W. Ng,
- Sara Rahmati,
- Zhaolin Xu,
- Megan Fuller,
- Katy Milne,
- Daniel Lu,
- Rocky Shi,
- David A. Rowbotham,
- Daiana D. Becker-Santos,
- Fraser D. Johnson,
- John C. English,
- Calum E. MacAulay,
- Stephen Lam,
- William W. Lockwood,
- Raj Chari,
- Aly Karsan,
- Igor Jurisica,
- Wan L. Lam
Affiliations
- Katey S. S. Enfield
- British Columbia Cancer Research Centre
- Erin A. Marshall
- British Columbia Cancer Research Centre
- Christine Anderson
- British Columbia Cancer Research Centre
- Kevin W. Ng
- British Columbia Cancer Research Centre
- Sara Rahmati
- Department of Medical Biophysics, University of Toronto
- Zhaolin Xu
- Dalhousie University
- Megan Fuller
- British Columbia Cancer Research Centre
- Katy Milne
- Deeley Research Centre
- Daniel Lu
- British Columbia Cancer Research Centre
- Rocky Shi
- British Columbia Cancer Research Centre
- David A. Rowbotham
- British Columbia Cancer Research Centre
- Daiana D. Becker-Santos
- British Columbia Cancer Research Centre
- Fraser D. Johnson
- British Columbia Cancer Research Centre
- John C. English
- Vancouver General Hospital
- Calum E. MacAulay
- British Columbia Cancer Research Centre
- Stephen Lam
- British Columbia Cancer Research Centre
- William W. Lockwood
- British Columbia Cancer Research Centre
- Raj Chari
- Frederick National Lab for Cancer Research, Laboratory Animal Sciences Program
- Aly Karsan
- British Columbia Cancer Research Centre
- Igor Jurisica
- Krembil Research Institute, University Health Network
- Wan L. Lam
- British Columbia Cancer Research Centre
- DOI
- https://doi.org/10.1038/s41467-019-13295-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Tissue context can dictate why a gene can have seemingly opposing functions in different settings. ELF3 is tumor suppressive in many cancers of epithelial origin but in lung cancer, the authors describe an oncogenic role in the adenocarcinoma histology of non-small cell lung cancer.
