Background: Medical Council of India emphasizes the need for self directed active learning among undergraduate students. Traditional lectures alone are poor means of transferring/acquiring information less effective at skill development. Hence it is the need of time to incorporate innovative teaching learning strategies in undergraduate MBBS curriculum so we planned to undertake a study to incorporate flipped classroom model in teaching Human Physiology. Methodology: One hundred and fifty students of first MBBS were divided two groups of 75 students each (Batch A and B) as per their roll calls. For the present study, students from Batch A (n = 75) were taken as cases and Batch B (n = 75) students were taken as controls. The control group attended traditional classes that involved didactic sessions while study population was exposed to Flipped classroom model. Student’s perceptions to Flipped classroom were obtained. Performance of students in flipped classroom is compared with that of the control population. Result: Students involved in the study group showed better performance and understanding of subject matter. Conclusion: Flipped classroom model make active student participation incultating key concepts in physiology in a playful learning environment making it an enjoyable, lovable learning experience.