Nature Communications (Mar 2021)
An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability
- Zsuzsanna Nagy,
- Janith A. Seneviratne,
- Maxwell Kanikevich,
- William Chang,
- Chelsea Mayoh,
- Pooja Venkat,
- Yanhua Du,
- Cizhong Jiang,
- Alice Salib,
- Jessica Koach,
- Daniel R. Carter,
- Rituparna Mittra,
- Tao Liu,
- Michael W. Parker,
- Belamy B. Cheung,
- Glenn M. Marshall
Affiliations
- Zsuzsanna Nagy
- Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW
- Janith A. Seneviratne
- Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW
- Maxwell Kanikevich
- Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW
- William Chang
- Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW
- Chelsea Mayoh
- Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW
- Pooja Venkat
- Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW
- Yanhua Du
- School of Life Sciences and Technology, Tongji University
- Cizhong Jiang
- School of Life Sciences and Technology, Tongji University
- Alice Salib
- Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW
- Jessica Koach
- Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW
- Daniel R. Carter
- Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW
- Rituparna Mittra
- Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW
- Tao Liu
- Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW
- Michael W. Parker
- Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne
- Belamy B. Cheung
- Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW
- Glenn M. Marshall
- Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW
- DOI
- https://doi.org/10.1038/s41467-021-22143-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 20
Abstract
Neuroblastoma (NB) is often driven by MYCN amplification. Here, the authors show that the most frequent genetic lesion, gain of 17q21-ter in NB leads to overexpression of ALYREF, which forms a complex with MYCN, regulating MYCN stability via the deubiquitinating enzyme, USP3.
