Customised 3D-Printed Surgical Guide for Breast-Conserving Surgery after Neoadjuvant Chemotherapy and Its Clinical Application

Jie Luo; Feng Chen; Hong Cao; Wei Zhu; Jian Deng; Dan Li; Wei Li; Junjie Deng; Yangyan Zhong; Haigang Feng; Yilin Li; Xiongmeiyu Gong; Jutao Zeng; Jiaren Chen

doi:10.3390/bioengineering10111296

Bioengineering (Nov 2023)

Customised 3D-Printed Surgical Guide for Breast-Conserving Surgery after Neoadjuvant Chemotherapy and Its Clinical Application

Jie Luo,
Feng Chen,
Hong Cao,
Wei Zhu,
Jian Deng,
Dan Li,
Wei Li,
Junjie Deng,
Yangyan Zhong,
Haigang Feng,
Yilin Li,
Xiongmeiyu Gong,
Jutao Zeng,
Jiaren Chen

Affiliations

Jie Luo: Department of Breast and Thyroid Surgery, Clinical Research Center for Breast & Thyroid Disease Prevention in Hunan Province (2018SK4001), The Second Hospital, University of South China, Hengyang 421001, China
Feng Chen: National Engineering Research Centre for High Efficiency Grinding, College of Mechanical and Vehicle Engineering, Hunan University, Changsha 410082, China
Hong Cao: Department of Breast and Thyroid Surgery, Clinical Research Center for Breast & Thyroid Disease Prevention in Hunan Province (2018SK4001), The Second Hospital, University of South China, Hengyang 421001, China
Wei Zhu: National Engineering Research Centre for High Efficiency Grinding, College of Mechanical and Vehicle Engineering, Hunan University, Changsha 410082, China
Jian Deng: Department of Breast and Thyroid Surgery, Clinical Research Center for Breast & Thyroid Disease Prevention in Hunan Province (2018SK4001), The Second Hospital, University of South China, Hengyang 421001, China
Dan Li: Department of Breast and Thyroid Surgery, Clinical Research Center for Breast & Thyroid Disease Prevention in Hunan Province (2018SK4001), The Second Hospital, University of South China, Hengyang 421001, China
Wei Li: Department of Breast and Thyroid Surgery, Clinical Research Center for Breast & Thyroid Disease Prevention in Hunan Province (2018SK4001), The Second Hospital, University of South China, Hengyang 421001, China
Junjie Deng: Department of Breast and Thyroid Surgery, Clinical Research Center for Breast & Thyroid Disease Prevention in Hunan Province (2018SK4001), The Second Hospital, University of South China, Hengyang 421001, China
Yangyan Zhong: Department of Breast and Thyroid Surgery, Clinical Research Center for Breast & Thyroid Disease Prevention in Hunan Province (2018SK4001), The Second Hospital, University of South China, Hengyang 421001, China
Haigang Feng: Department of Breast and Thyroid Surgery, Clinical Research Center for Breast & Thyroid Disease Prevention in Hunan Province (2018SK4001), The Second Hospital, University of South China, Hengyang 421001, China
Yilin Li: Department of Breast and Thyroid Surgery, Clinical Research Center for Breast & Thyroid Disease Prevention in Hunan Province (2018SK4001), The Second Hospital, University of South China, Hengyang 421001, China
Xiongmeiyu Gong: Department of Breast and Thyroid Surgery, Clinical Research Center for Breast & Thyroid Disease Prevention in Hunan Province (2018SK4001), The Second Hospital, University of South China, Hengyang 421001, China
Jutao Zeng: Department of Breast and Thyroid Surgery, Clinical Research Center for Breast & Thyroid Disease Prevention in Hunan Province (2018SK4001), The Second Hospital, University of South China, Hengyang 421001, China
Jiaren Chen: Department of Breast and Thyroid Surgery, Clinical Research Center for Breast & Thyroid Disease Prevention in Hunan Province (2018SK4001), The Second Hospital, University of South China, Hengyang 421001, China

DOI: https://doi.org/10.3390/bioengineering10111296
Journal volume & issue: Vol. 10, no. 11
p. 1296

Abstract

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For patients eligible to undergo breast-conserving surgery (BCS) after neoadjuvant chemotherapy, accurate preoperative localisation of tumours is vital to ensure adequate tumour resection that can reduce recurrence probability effectively. For this reason, we have developed a 3D-printed personalised breast surgery guide (BSG) assisted with supine magnetic resonance imaging (MRI) and image 3D reconstruction technology, capable of mapping the tumour area identified on MRI onto the breast directly using dual positioning based on the manubrium and nipple. In addition, the BSG allows the colour dye to be injected into the breast to mark the tumour region to be removed, yielding more accurate intraoperative resection and satisfactory cosmetic outcomes. The device has been applied to 14 patients from January 2018 to July 2023, with two positive margins revealed by the intraoperative biopsy. This study showed that the BSG-based method could facilitate precise tumour resection of BCS by accurately localising tumour extent and margin, promoting the clinical efficacy in patients with breast cancer as well as simplifying the surgical process.

Published in Bioengineering

ISSN: 2306-5354 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology; Science: Biology (General)
Website: https://www.mdpi.com/journal/bioengineering

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