Communications Biology (Sep 2021)

Hypoxia inducible factor signaling in breast tumors controls spontaneous tumor dissemination in a site-specific manner

  • Vera M. Todd,
  • Lawrence A. Vecchi,
  • Miranda E. Clements,
  • Katherine P. Snow,
  • Cayla D. Ontko,
  • Lauren Himmel,
  • Christopher Pinelli,
  • Marjan Rafat,
  • Rachelle W. Johnson

DOI
https://doi.org/10.1038/s42003-021-02648-3
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 18

Abstract

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Todd et al employ a PyMT-driven spontaneous murine mammary carcinoma model with mammary-specific deletion of hypoxia inducible factors Hif1α, Hif2α, or von Hippel-Lindau factor to further investigate their role in bone and lung metastasis. They find that HIF signaling in breast tumours controls tumour dissemination in a site-specific manner, which could inform the development of therapies targeting metastasis.