Nature Communications (Dec 2021)

Reinforcing the supply chain of umifenovir and other antiviral drugs with retrosynthetic software

  • Yingfu Lin,
  • Zirong Zhang,
  • Babak Mahjour,
  • Di Wang,
  • Rui Zhang,
  • Eunjae Shim,
  • Andrew McGrath,
  • Yuning Shen,
  • Nadia Brugger,
  • Rachel Turnbull,
  • Sarah Trice,
  • Shashi Jasty,
  • Tim Cernak

DOI
https://doi.org/10.1038/s41467-021-27547-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 8

Abstract

Read online

COVID-19 has exposed the fragility of supply chains, particularly for goods that are essential or may suddenly become essential, such as repurposed pharmaceuticals. Here the authors develop a methodology to provide routes to pharmaceutical targets that allow low-supply starting materials or intermediates to be avoided, with representative pathways validated experimentally.