Nature Communications (Dec 2021)
Reinforcing the supply chain of umifenovir and other antiviral drugs with retrosynthetic software
Abstract
COVID-19 has exposed the fragility of supply chains, particularly for goods that are essential or may suddenly become essential, such as repurposed pharmaceuticals. Here the authors develop a methodology to provide routes to pharmaceutical targets that allow low-supply starting materials or intermediates to be avoided, with representative pathways validated experimentally.