Medicinski Podmladak (Jan 2019)
Pathohistological characteristics of steatohepatitis on needle biopsy sample from 100 patients
Abstract
Introduction: Steatohepatitis is a form of fatty liver disease, in which there is a deposit of fat and steatosis which occurs in two forms: alcoholic and non-alcoholic fatty liver disease. When there is simultaneous inflammation, it is defined as steatohepatitis, which can be divided into alcoholic steatohepatitis and non-alcoholic steatohepatitis. Alcoholic and non-alcoholic steatohepatitis show identical morphological features characterized by steatosis, hepatocellular changes with ballooning degeneration of hepatocytes, the presence of Mallory-Denk hyaline, apoptosis, necrosis, subsequent inflammation of the liver parenchyma and fibrosis. Aim: The aim of this paper is to record all pathohistological changes in puncture biopsy patterns of the liver of patients with steatohepatitis, grading these changes and determining their correlation with the age and sex of patients, as well as the correlation of the most important pathohistological changes. Material and methods: Retrospective research included core needle biopsy from the right lobe of the liver, in patients with pathohistological diagnosis of steatohepatitis. For statistical data processing Spearman's and Chi-squared test in the SPSS program were used, and p < 0.05 was used as the minimum statistically significant value. Results: Our research included 100 respondents from alcoholic and non-alcoholic steatohepatitis, 62% males and 38% females. Necroinflammatory activity was significantly greater in respondents with greater volume of steatosis. There is also a positive correlation between the degree of necroinflammatory activity and the degree of fibrosis. Higher necroinflammatory activity is associated with a higher degree of fibrosis. Conclusion: In our research, most of the respondents had steatohepatitis of minimal activity and without fibrosis or with light fibrosis. Respondents with a higher volume of steatosis had higher necroinflammatory activity in the liver. Respondents with steatohepatitis and greater necroinflammatory activity also had a higher stage of the disease (a higher degree of fibrosis). The age and sex of respondents were not correlated with the degree of fibrosis.
