急性缺血性卒中血管内治疗术后血清前白蛋白水平与预后的相关性研究 Correlation of Hypoprealbuminemia and Outcome after Endovascular Treatment for Acute Ischemic Stroke

Abstract

目的 探讨急性缺血性卒中血管内治疗术后低血清前白蛋白血症的发生情况及其与预后的相关性。 方法 本研究前瞻性连续收集2017年7月-2020年10月来自全国18家分中心，符合条件的急性缺血性卒中血管内治疗患者的数据。依据患者血管内治疗术后24 h内的血清前白蛋白水平分为低前白蛋白组和正常前白蛋白组，低前白蛋白定义为血管内治疗术后24 h内患者一次或多次血清前白蛋白水平0.05）。 结论 对于急性缺血性卒中血管内治疗术后患者，低前白蛋白血症发生与发病90 d不良预后发生有显著相关性. Abstract: Objective To explore the occurrence of serum hypoprealbuminemia and its correlation with prognosis after endovascular treatment of acute ischemic stroke. Methods This study prospectively collected the data of patients who underwent endovascular treatment for acute ischemic stroke in 18 sub-centers in China from July 2017 to October 2020. According to serum prealbumin level within 24 hours after surgery, the patients were divided into low prealbumin group and normal prealbumin group. Low prealbumin was defined as the serum prealbumin level is lower than 170 mg/L within 24 hours after endovascular therapy in one or more detections. Good prognosis was defined as a mRS score of 0-2. The logistic regression analysis was used to evaluate the correlation of low prealbumin level with short-term prognosis and long-term (90 days) prognosis. The short-term prognosis included early neurological deterioration, any intracranial hemorrhage within 72 hours after surgery. The mRS was used to evaluate 90-day prognosis. Results A total of 1254 patients was included in this study, including 289 patients (23.05%) in low prealbumin group and 965 (76.95%) in normal prealbumin group. Logistic regression analysis showed that the low prealbumin level was an independent influencing factor for 90-day good prognosis (aOR 0.48, 95%CI 0.35-0.66, P0.05). Conclusions For acute ischemic stroke patients after endovascular therapy, the occurrence of hypoprealbuminemia was correlated with 90-day poor prognosis.

Keywords

• 缺血性卒中
• 血管内治疗
• 前白蛋白
• ischemic stroke
• endovascular treatment
• prealbumin