Nature Communications (Aug 2021)
O-GlcNAcylated p53 in the liver modulates hepatic glucose production
- Maria J. Gonzalez-Rellan,
- Marcos F. Fondevila,
- Uxia Fernandez,
- Amaia Rodríguez,
- Marta Varela-Rey,
- Christelle Veyrat-Durebex,
- Samuel Seoane,
- Ganeko Bernardo,
- Fernando Lopitz-Otsoa,
- David Fernández-Ramos,
- Jon Bilbao,
- Cristina Iglesias,
- Eva Novoa,
- Cristina Ameneiro,
- Ana Senra,
- Daniel Beiroa,
- Juan Cuñarro,
- Maria DP Chantada-Vazquez,
- Maria Garcia-Vence,
- Susana B. Bravo,
- Natalia Da Silva Lima,
- Begoña Porteiro,
- Carmen Carneiro,
- Anxo Vidal,
- Sulay Tovar,
- Timo D. Müller,
- Johan Ferno,
- Diana Guallar,
- Miguel Fidalgo,
- Guadalupe Sabio,
- Stephan Herzig,
- Won Ho Yang,
- Jin Won Cho,
- Maria Luz Martinez-Chantar,
- Roman Perez-Fernandez,
- Miguel López,
- Carlos Dieguez,
- Jose M. Mato,
- Oscar Millet,
- Roberto Coppari,
- Ashwin Woodhoo,
- Gema Fruhbeck,
- Ruben Nogueiras
Affiliations
- Maria J. Gonzalez-Rellan
- CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Marcos F. Fondevila
- CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Uxia Fernandez
- CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Amaia Rodríguez
- CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn)
- Marta Varela-Rey
- Liver Disease Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE, Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park
- Christelle Veyrat-Durebex
- Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva
- Samuel Seoane
- CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Ganeko Bernardo
- Precision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance
- Fernando Lopitz-Otsoa
- Precision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance
- David Fernández-Ramos
- CIBERehd, Instituto de Salud Carlos III
- Jon Bilbao
- Precision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance
- Cristina Iglesias
- CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Eva Novoa
- CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Cristina Ameneiro
- CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Ana Senra
- CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Daniel Beiroa
- CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Juan Cuñarro
- CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Maria DP Chantada-Vazquez
- Proteomic Unit, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela
- Maria Garcia-Vence
- Proteomic Unit, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela
- Susana B. Bravo
- Proteomic Unit, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela
- Natalia Da Silva Lima
- CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Begoña Porteiro
- CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Carmen Carneiro
- CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Anxo Vidal
- CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Sulay Tovar
- CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Timo D. Müller
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC) at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH) and German Center for Diabetes Research (DZD)
- Johan Ferno
- Hormone Laboratory, Haukeland University Hospital
- Diana Guallar
- CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Miguel Fidalgo
- CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Guadalupe Sabio
- Centro Nacional de Investigaciones Cardiovasculares (CNIC)
- Stephan Herzig
- Institute for Diabetes and Cancer (IDC) and Joint Heidelberg-IDC Translational Diabetes Program, Helmholtz Center Munich
- Won Ho Yang
- Department of Systems Biology, Yonsei University
- Jin Won Cho
- Department of Systems Biology, Yonsei University
- Maria Luz Martinez-Chantar
- Liver Disease Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE, Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park
- Roman Perez-Fernandez
- CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Miguel López
- CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Carlos Dieguez
- CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Jose M. Mato
- Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva
- Oscar Millet
- Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva
- Roberto Coppari
- CIBERehd, Instituto de Salud Carlos III
- Ashwin Woodhoo
- IKERBASQUE, Basque Foundation for Science
- Gema Fruhbeck
- CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn)
- Ruben Nogueiras
- CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- DOI
- https://doi.org/10.1038/s41467-021-25390-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 21
Abstract
p53 regulates signalling pathways involved in metabolic homeostasis. Here the authors show that O-GlcNAcylation of p53 in the liver plays a key role in the physiological regulation of glucose homeostasis, potentially via controlling the expression of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase.
