Nature Communications (Aug 2022)
Levels of SARS-CoV-2 antibodies among fully vaccinated individuals with Delta or Omicron variant breakthrough infections
- Nina Breinholt Stærke,
- Joanne Reekie,
- Henrik Nielsen,
- Thomas Benfield,
- Lothar Wiese,
- Lene Surland Knudsen,
- Mette Brouw Iversen,
- Kasper Iversen,
- Kamille Fogh,
- Jacob Bodilsen,
- Maria Ruwald Juhl,
- Susan Olaf Lindvig,
- Anne Øvrehus,
- Lone Wulff Madsen,
- Vibeke Klastrup,
- Sidsel Dahl Andersen,
- Anna Karina Juhl,
- Signe Rode Andreasen,
- Sisse Rye Ostrowski,
- Christian Erikstrup,
- Thea K. Fischer,
- Martin Tolstrup,
- Lars Østergaard,
- Isik Somuncu Johansen,
- Jens Lundgren,
- Ole Schmeltz Søgaard
Affiliations
- Nina Breinholt Stærke
- Department of Infectious Diseases, Aarhus University Hospital
- Joanne Reekie
- Center of Excellence for Health, Immunity and Infections, Rigshospitalet, University of Copenhagen
- Henrik Nielsen
- Department of Infectious Diseases, Aalborg University Hospital
- Thomas Benfield
- Department of Infectious Diseases, Copenhagen University Hospital—Amager and Hvidovre
- Lothar Wiese
- Department of Medicine, Zealand University Hospital
- Lene Surland Knudsen
- Department of Medicine, Zealand University Hospital
- Mette Brouw Iversen
- Department of Medicine, Zealand University Hospital
- Kasper Iversen
- Department of Cardiology and Department of Emergency Medicine, Herlev-Gentofte Hospital
- Kamille Fogh
- Department of Cardiology and Department of Emergency Medicine, Herlev-Gentofte Hospital
- Jacob Bodilsen
- Department of Infectious Diseases, Aalborg University Hospital
- Maria Ruwald Juhl
- Department of Infectious Diseases, Aalborg University Hospital
- Susan Olaf Lindvig
- Department of Infectious Diseases, Odense University Hospital
- Anne Øvrehus
- Department of Infectious Diseases, Odense University Hospital
- Lone Wulff Madsen
- Department of Infectious Diseases, Odense University Hospital
- Vibeke Klastrup
- Department of Infectious Diseases, Aarhus University Hospital
- Sidsel Dahl Andersen
- Department of Infectious Diseases, Aarhus University Hospital
- Anna Karina Juhl
- Department of Infectious Diseases, Aarhus University Hospital
- Signe Rode Andreasen
- Department of Infectious Diseases, Aarhus University Hospital
- Sisse Rye Ostrowski
- Departments of Clinical Medicine and Public Health, University of Copenhagen
- Christian Erikstrup
- Department of Clinical Medicine, Aarhus University
- Thea K. Fischer
- Departments of Clinical Medicine and Public Health, University of Copenhagen
- Martin Tolstrup
- Department of Infectious Diseases, Aarhus University Hospital
- Lars Østergaard
- Department of Infectious Diseases, Aarhus University Hospital
- Isik Somuncu Johansen
- Department of Infectious Diseases, Odense University Hospital
- Jens Lundgren
- Center of Excellence for Health, Immunity and Infections, Rigshospitalet, University of Copenhagen
- Ole Schmeltz Søgaard
- Department of Infectious Diseases, Aarhus University Hospital
- DOI
- https://doi.org/10.1038/s41467-022-32254-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 8
Abstract
The SARS-CoV-2 Omicron variant is associated with high rates of vaccine breakthrough infections, but the immunological basis for this is not well characterised. Here, the authors show that increased anti-Spike IgG antibody levels are associated with a reduced risk of infection with the Delta variant, but not with Omicron.
