Metaepigenomic analysis reveals the unexplored diversity of DNA methylation in an environmental prokaryotic community

Satoshi Hiraoka; Yusuke Okazaki; Mizue Anda; Atsushi Toyoda; Shin-ichi Nakano; Wataru Iwasaki

doi:10.1038/s41467-018-08103-y

Nature Communications (Jan 2019)

Metaepigenomic analysis reveals the unexplored diversity of DNA methylation in an environmental prokaryotic community

Satoshi Hiraoka,
Yusuke Okazaki,
Mizue Anda,
Atsushi Toyoda,
Shin-ichi Nakano,
Wataru Iwasaki

Affiliations

Satoshi Hiraoka: Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo
Yusuke Okazaki: Center for Ecological Research, Kyoto University
Mizue Anda: Department of Biological Sciences, Graduate School of Science, The University of Tokyo
Atsushi Toyoda: National Institute of Genetics
Shin-ichi Nakano: Center for Ecological Research, Kyoto University
Wataru Iwasaki: Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo

DOI: https://doi.org/10.1038/s41467-018-08103-y
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

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Our knowledge of DNA methylation systems in prokaryotes is mostly limited to those of culturable microbes. Here, Hiraoka et al. analyse DNA methylation patterns in metagenomic data from a microbial community, revealing new methylated motifs and experimentally validating the methyltransferases’ specificities.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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