Nature Communications (Jul 2019)

EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming

  • Nicolas Istaces,
  • Marion Splittgerber,
  • Viviana Lima Silva,
  • Muriel Nguyen,
  • Séverine Thomas,
  • Aurore Le,
  • Younes Achouri,
  • Emilie Calonne,
  • Matthieu Defrance,
  • François Fuks,
  • Stanislas Goriely,
  • Abdulkader Azouz

DOI
https://doi.org/10.1038/s41467-019-11233-6
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 17

Abstract

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T box transcription factor Eomesodermin (EOMES) is induced when naïve T cells are converted to innate memory T cells in response to cytokines. Here the authors show that EOMES is recruited to RUNX3-bound enhancers and interacts with BRG1 during innate memory T cell formation.