Nature Communications (Feb 2022)

Broadly neutralizing anti-HIV-1 antibodies tether viral particles at the surface of infected cells

  • Jérémy Dufloo,
  • Cyril Planchais,
  • Stéphane Frémont,
  • Valérie Lorin,
  • Florence Guivel-Benhassine,
  • Karl Stefic,
  • Nicoletta Casartelli,
  • Arnaud Echard,
  • Philippe Roingeard,
  • Hugo Mouquet,
  • Olivier Schwartz,
  • Timothée Bruel

DOI
https://doi.org/10.1038/s41467-022-28307-7
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 11

Abstract

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Broadly neutralizing antibodies (bNAbs) neutralize HIV-1 and exert Fc-dependent activities against infected cells. Here, Dufloo et al. show that bNAbs also block HIV-1 release by trapping viral particles at the surface of infected cells.