Prognostic value of coagulation markers in patients with colorectal cancer: A prospective study

Abstract

Abstract Background and Aims The occurrence, growth, and metastasis of colorectal cancer (CRC) are connected to the hypercoagulable state of blood (CRC). This study aimed to identify significant coagulation factors to predict metastasis and prognosis of CRC. Methods Thrombomodulin (TM), thrombin‐antithrombin complex (TAT), α2‐plasmininhibitor‐plasmin complex (PIC), and tissue plasminogen activator‐inhibitor complex (t‐PAIC) were detected by chemiluminescence immunoassay using Sysmex HISCL5000 automated analyzers. The Sysmex CS 5100 automatic blood coagulation analyzer was used to detect d‐dimer (DD), fibrin degradation product (FDP), prothrombin time (PT), thrombin time (TT), international normalized ratio (INR), fibrinogen (Fbg), and activated partial thromboplastin time (APTT). Area under the curve (AUC) and the receiver operating characteristic curve (ROC) were used to assess the diagnostic efficacy of markers. Kaplan–Meier analysis was used to calculate survival probabilities. Independent prognostic factors and the nomogram were developed using single‐factor and multifactor cox regression analysis model. Results The following indicators (TM, TAT, PIC, t‐PAIC, DD, FDP, PT, INR, APTT, and Fbg) were markedly higher in CRC patients than in healthy controls, and they were higher in the metastasis (M) group than in the nonmetastasis (NM) group. The combination “TAT + PIC + DD + FDP + Fbg” can distinguish M from NM with exceptional sensitivity and specificity. Patients with CRC who had high levels of TAT, PIC, DD, FDP, Fbg, TM, tPAIC, PT, and INR had significantly shorter survival. Conclusion The prognosis of CRC patients can be predicted by coagulation indicators. The independent predictive variables for overall survival were found to be TM and DD. To forecast CRC patient survival, a nomogram was created.

Keywords

• coagulation
• colorectal cancer
• diagnosis
• nomogram
• prognosis