Aim – assessment of the influence of inhaled nitric oxide (NO) on the course of pulmonary hypertension (PH) in patients with chronic heartfailure (CHF) III–IV functional class (FC), myocardial infarction (MI).Materials and methods. Results of comparative non-randomized study that included 45 patients (26 men and 19 women aged 51 to 98 years) with PH III–IV functional class, left ventricular myocardial infarction. In the study, patients underwent physical examination and Doppler echocardiography, and assessed FC LH (carried out with six-minute walking test, to determine the degree of dyspnea by Borg).Results. Symptoms of CHF and PH regressed in both groups of patients against the background of the therapy. Conclusion. It is established that the use of inhaled NO is a safe therapy and helps to reduce mean pulmonary arterial pressure (PAPmean) in patients with PH and CHF III–IV FC, myocardial infarction. The method of inhaled NO is simple and easy to use.