Nature Communications (May 2021)

Interplay between transforming growth factor-β and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis

  • Boning Niu,
  • Jie Liu,
  • Ben Lv,
  • Jiacheng Lin,
  • Xin Li,
  • Chunxiao Wu,
  • Xiaohua Jiang,
  • Zhiping Zeng,
  • Xiao-kun Zhang,
  • Hu Zhou

DOI
https://doi.org/10.1038/s41467-021-23048-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 17

Abstract

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Inhibitor of Differentiation 1 (ID1) is an oncogene for colorectal cancer. Here, the authors show a complex interplay between nuclear receptor Nur77 and Transforming Growth Factor-β (TGFβ) to regulate ID1 expression at both transcriptional and post-translational levels which is relevant to colon cancer stemness, metastasis and resistance to oxaliplatin.