BMC Medical Research Methodology (Apr 2022)
Methodology and experiences of rapid advice guideline development for children with COVID-19: responding to the COVID-19 outbreak quickly and efficiently
- Qi Zhou,
- Qinyuan Li,
- Janne Estill,
- Qi Wang,
- Zijun Wang,
- Qianling Shi,
- Jingyi Zhang,
- Xiaobo Zhang,
- Joseph L. Mathew,
- Rosalind L. Smyth,
- Detty Nurdiati,
- Zhou Fu,
- Hongmei Xu,
- Xianlan Zheng,
- Xiaodong Zhao,
- Quan Lu,
- Hui Liu,
- Yangqin Xun,
- Weiguo Li,
- Shu Yang,
- Xixi Feng,
- Mengshu Wang,
- Junqiang Lei,
- Xiaoping Luo,
- Liqun Wu,
- Xiaoxia Lu,
- Myeong Soo Lee,
- Shunying Zhao,
- Edwin Shih-Yen Chan,
- Yuan Qian,
- Wenwei Tu,
- Xiaoyan Dong,
- Guobao Li,
- Ruiqiu Zhao,
- Zhihui He,
- Siya Zhao,
- Xiao Liu,
- Qiu Li,
- Kehu Yang,
- Zhengxiu Luo,
- Enmei Liu,
- Yaolong Chen
Affiliations
- Qi Zhou
- Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University
- Qinyuan Li
- Department of Respiratory Medicine Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics
- Janne Estill
- Institute of Global Health, University of Geneva
- Qi Wang
- Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University
- Zijun Wang
- Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University
- Qianling Shi
- The First School of Clinical Medicine, Lanzhou University
- Jingyi Zhang
- School of Public Health, Lanzhou University
- Xiaobo Zhang
- Children’s Hospital of Fudan University, National Children’s Medical Center
- Joseph L. Mathew
- Advanced Pediatrics Centre, PGIMER Chandigarh
- Rosalind L. Smyth
- UCL Great Ormond Street Institute of Child Health
- Detty Nurdiati
- Cochrane Indonesia, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada
- Zhou Fu
- Department of Respiratory Medicine Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics
- Hongmei Xu
- Department of Infection Diseases Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics
- Xianlan Zheng
- Department of Nursing Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics
- Xiaodong Zhao
- Department of Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children’s Hospital of Chongqing Medical University
- Quan Lu
- Shanghai Children’s Hospital Affiliated To Shanghai Jiaotong University
- Hui Liu
- School of Public Health, Lanzhou University
- Yangqin Xun
- Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University
- Weiguo Li
- Department of Respiratory Medicine Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics
- Shu Yang
- Digital Institute of Medicine, Chengdu University of Traditional Chinese Medicine
- Xixi Feng
- Department of Public Health, Chengdu Medical College
- Mengshu Wang
- Department of Radiology, the First Hospital of Lanzhou University
- Junqiang Lei
- Department of Radiology, the First Hospital of Lanzhou University
- Xiaoping Luo
- Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Liqun Wu
- Shenzhen Health Development Research Center
- Xiaoxia Lu
- Department of Respiratory Medicine, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Myeong Soo Lee
- Clinical Medicine Division, Korea Institute of Oriental Medicine
- Shunying Zhao
- Beijing Children’s Hospital
- Edwin Shih-Yen Chan
- Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-National University of Singapore Medical School
- Yuan Qian
- Beijing Key Laboratory of Etiology of Viral Diseases in Children, Capital Institute of Pediatrics
- Wenwei Tu
- Department of Pediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong
- Xiaoyan Dong
- Shanghai Children’s Hospital
- Guobao Li
- National Clinical Research Center for Infectious Disease
- Ruiqiu Zhao
- Department of Infection Diseases Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics
- Zhihui He
- Chongqing Ninth People’s Hospital
- Siya Zhao
- School of Public Health, Lanzhou University
- Xiao Liu
- School of Public Health, Lanzhou University
- Qiu Li
- Department of Nephrology Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics
- Kehu Yang
- Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University
- Zhengxiu Luo
- Department of Respiratory Medicine Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics
- Enmei Liu
- Department of Respiratory Medicine Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics
- Yaolong Chen
- Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University
- DOI
- https://doi.org/10.1186/s12874-022-01545-5
- Journal volume & issue
-
Vol. 22,
no. 1
pp. 1 – 24
Abstract
Abstract Background Rapid Advice Guidelines (RAG) provide decision makers with guidance to respond to public health emergencies by developing evidence-based recommendations in a short period of time with a scientific and standardized approach. However, the experience from the development process of a RAG has so far not been systematically summarized. Therefore, our working group will take the experience of the development of the RAG for children with COVID-19 as an example to systematically explore the methodology, advantages, and challenges in the development of the RAG. We shall propose suggestions and reflections for future research, in order to provide a more detailed reference for future development of RAGs. Result The development of the RAG by a group of 67 researchers from 11 countries took 50 days from the official commencement of the work (January 28, 2020) to submission (March 17, 2020). A total of 21 meetings were held with a total duration of 48 h (average 2.3 h per meeting) and an average of 16.5 participants attending. Only two of the ten recommendations were fully supported by direct evidence for COVID-19, three recommendations were supported by indirect evidence only, and the proportion of COVID-19 studies among the body of evidence in the remaining five recommendations ranged between 10 and 83%. Six of the ten recommendations used COVID-19 preprints as evidence support, and up to 50% of the studies with direct evidence on COVID-19 were preprints. Conclusions In order to respond to public health emergencies, the development of RAG also requires a clear and transparent formulation process, usually using a large amount of indirect and non-peer-reviewed evidence to support the formation of recommendations. Strict following of the WHO RAG handbook does not only enhance the transparency and clarity of the guideline, but also can speed up the guideline development process, thereby saving time and labor costs.
Keywords
