Pay attention to the value of autonomic dysfunction in diagnosing and prognosis prediction of central α⁃synucleinopathy

Abstract

Central α‑synucleinopathy includes Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). The clinical manifestations of these diseases usually overlap, which make the differential diagnosis difficult in clinical practice. Autonomic dysfunction is a common feature of these diseases. Recent studies indicated the autonomic dysfunction would contribute to our further understanding of central α‑synucleinopathy. This article reviews the value of autonomic dysfunction in the predictive diagnosis, differential diagnosis and prognosis of the above diseases, to help clinical practice.

Keywords

• synucleinopathies
• autonomic nervous system
• review