Nature Communications (Jan 2021)
LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis
- Huai-Bin Hu,
- Zeng-Qing Song,
- Guang-Ping Song,
- Sen Li,
- Hai-Qing Tu,
- Min Wu,
- Yu-Cheng Zhang,
- Jin-Feng Yuan,
- Ting-Ting Li,
- Pei-Yao Li,
- Yu-Ling Xu,
- Xiao-Lin Shen,
- Qiu-Ying Han,
- Ai-Ling Li,
- Tao Zhou,
- Jerold Chun,
- Xue-Min Zhang,
- Hui-Yan Li
Affiliations
- Huai-Bin Hu
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Zeng-Qing Song
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Guang-Ping Song
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Sen Li
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Hai-Qing Tu
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Min Wu
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Yu-Cheng Zhang
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Jin-Feng Yuan
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Ting-Ting Li
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Pei-Yao Li
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Yu-Ling Xu
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Xiao-Lin Shen
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Qiu-Ying Han
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Ai-Ling Li
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Tao Zhou
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Jerold Chun
- Sanford Burnham Prebys Medical Discovery Institute
- Xue-Min Zhang
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Hui-Yan Li
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- DOI
- https://doi.org/10.1038/s41467-021-20986-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Dynamic assembly and disassembly of primary cilia is critical for tissue development and homeostasis. Here the authors identify lysophosphatidic acid (LPA) as a physiological extracellular factor that initiates cilia disassembly through both YAP/TAZ mediated transcription and calcium/calmodulin mediated activation of Aurora A.
