Anaplasma phagocytophilum Hijacks Flotillin and NPC1 Complex To Acquire Intracellular Cholesterol for Proliferation, Which Can Be Inhibited with Ezetimibe
Weiyan Huang,
Qingming Xiong,
Mingqun Lin,
Yasuko Rikihisa
Affiliations
Weiyan Huang
Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA
Qingming Xiong
Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA
Mingqun Lin
Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA
Cholesterol influences membrane fluidity and forms membrane microdomains called lipid rafts that serve as organizing centers for the assembly of signaling molecules. Flotillin (FLOT) is a cholesterol-binding lipid-raft protein.
