Linear mitochondrial DNA is rapidly degraded by components of the replication machinery

Viktoriya Peeva; Daniel Blei; Genevieve Trombly; Sarah Corsi; Maciej J. Szukszto; Pedro Rebelo-Guiomar; Payam A. Gammage; Alexei P. Kudin; Christian Becker; Janine Altmüller; Michal Minczuk; Gábor Zsurka; Wolfram S. Kunz

doi:10.1038/s41467-018-04131-w

Nature Communications (Apr 2018)

Linear mitochondrial DNA is rapidly degraded by components of the replication machinery

Viktoriya Peeva,
Daniel Blei,
Genevieve Trombly,
Sarah Corsi,
Maciej J. Szukszto,
Pedro Rebelo-Guiomar,
Payam A. Gammage,
Alexei P. Kudin,
Christian Becker,
Janine Altmüller,
Michal Minczuk,
Gábor Zsurka,
Wolfram S. Kunz

Affiliations

Viktoriya Peeva: Institute of Experimental Epileptology and Cognition Research, University of Bonn
Daniel Blei: Institute of Experimental Epileptology and Cognition Research, University of Bonn
Genevieve Trombly: Institute of Experimental Epileptology and Cognition Research, University of Bonn
Sarah Corsi: Institute of Experimental Epileptology and Cognition Research, University of Bonn
Maciej J. Szukszto: MRC Mitochondrial Biology Unit, University of Cambridge
Pedro Rebelo-Guiomar: MRC Mitochondrial Biology Unit, University of Cambridge
Payam A. Gammage: MRC Mitochondrial Biology Unit, University of Cambridge
Alexei P. Kudin: Institute of Experimental Epileptology and Cognition Research, University of Bonn
Christian Becker: Cologne Center for Genomics, Center for Molecular Medicine Cologne (CMMC), University of Cologne
Janine Altmüller: Cologne Center for Genomics, Center for Molecular Medicine Cologne (CMMC), University of Cologne
Michal Minczuk: MRC Mitochondrial Biology Unit, University of Cambridge
Gábor Zsurka: Institute of Experimental Epileptology and Cognition Research, University of Bonn
Wolfram S. Kunz: Institute of Experimental Epileptology and Cognition Research, University of Bonn

DOI: https://doi.org/10.1038/s41467-018-04131-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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Damaged linearized mtDNA needs to be removed from the cell for mitochondrial genome stability. Here the authors shed light into the identity of the machinery responsible for rapidly degrading linearized DNA, implicating the role of mtDNA replication factors.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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