Somatic point mutations are enriched in non-coding RNAs with possible regulatory function in breast cancer

Narges Rezaie; Masroor Bayati; Mehrab Hamidi; Maedeh Sadat Tahaei; Sadegh Khorasani; Nigel H. Lovell; James Breen; Hamid R. Rabiee; Hamid Alinejad-Rokny

doi:10.1038/s42003-022-03528-0

Communications Biology (Jun 2022)

Somatic point mutations are enriched in non-coding RNAs with possible regulatory function in breast cancer

Narges Rezaie,
Masroor Bayati,
Mehrab Hamidi,
Maedeh Sadat Tahaei,
Sadegh Khorasani,
Nigel H. Lovell,
James Breen,
Hamid R. Rabiee,
Hamid Alinejad-Rokny

Affiliations

Narges Rezaie: Center for Complex Biological Systems, University of California Irvine
Masroor Bayati: Bioinformatics and Computational Biology Lab, Department of Computer Engineering, Sharif University of Technology
Mehrab Hamidi: Bioinformatics and Computational Biology Lab, Department of Computer Engineering, Sharif University of Technology
Maedeh Sadat Tahaei: Bioinformatics and Computational Biology Lab, Department of Computer Engineering, Sharif University of Technology
Sadegh Khorasani: Bioinformatics and Computational Biology Lab, Department of Computer Engineering, Sharif University of Technology
Nigel H. Lovell: Tyree Institute of Health Engineering and The Graduate School of Biomedical Engineering, UNSW Sydney
James Breen: South Australian Health & Medical Research Institute
Hamid R. Rabiee: Bioinformatics and Computational Biology Lab, Department of Computer Engineering, Sharif University of Technology
Hamid Alinejad-Rokny: BioMedical Machine Learning Lab (BML), The Graduate School of Biomedical Engineering, UNSW Sydney

DOI: https://doi.org/10.1038/s42003-022-03528-0
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

Read online

The SomaGene tool is developed to identify non-coding RNAs (ncRNAs) mutated in breast cancer but can be used for other cancers. Candidate ncRNAs are shown to be enriched for regulatory features and to contain specific trait loci polymorphisms.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal